The Greater Syracuse Chamber of Commerce is the largest business organization in Central New York. Since its inception in 1899, the Chamber has built upon its original mission to assist local businesses by leading the way in government relations, economic development, and nurturing entrepreneurs. Please note for active members, we are in the process of switching to a new payment processing system website to process your merchant dues. If you have any issues with the new processor, please contact us. The Chamber's Entrepreneurial Council is committed to building a community that understands and supports entrepreneurial activity.